58th Annual Spring Symposium -- Self-Assessment Module Credit (SAM)

This activity also incorporates the Self-Assessment Modules (SAMs) credits required by the American Board of Pathology’s Maintenance of Certification (MOC) Program. Physicians may claim up to 7 SAM credits for this activity. Claimed credit should commensurate with the extent of participation in the activity.


1. In contrast to the cells of GCNIS, germ cells with delayed maturation: *
2. The distinction of prepubertal-type teratoma from postpubertal-type teratoma is based on: *
3. Which one of the following is not a valid reason for classifying spermatocytic tumor apart from seminoma? *
4. Gonadoblastoma: *
5. Clear cell papilary renal cell carcinoma is a
6) Xp11 translocation renal cell carcinomas are *
7) Hereditary leiomyomatosis renal cell carcinoma is *
8) Which of the following is true of succinate dehydrogenase deficient renal cell carcinoma (SDH-deficient RCC)? *
9) In a cystoprostatectomy specimen performed for urothelial carcinoma of the urinary bladder, sections form the prostatic urethra show urothelial carcinoma in-situ associated with invasion into underlying prostatic stroma. Based on the 8th AJCC Cancer Staging Manual, the best stage for that specific carcinoma is: *
10) The presence of a primary bladder carcinoma with infiltrating signet ring-like cells in the absence of extracellular mucin would favor which subtype/variant based of WHO 2016 criteria? *
11) In general, for a carcinoma arising in a bladder diverticulum, which stage should NOT be assigned? *
12) Which of the following histologic type of renal cell carcinoma is the LEAST common in adult? *
13) Which of the following is a CORRECT statement regarding the utility of immunohistochemistry in the diagnosis of renal mass biopsy? *
14) For a renal cell neoplasm with papillary growth pattern and high nuclear grade, the most likely differential diagnoses are: *
15) The novel molecular based taxonomy for Muscle invasive bladder cancer given the TCGA findings include: *
16) In Muscle Invasive bladder cancer the following statement(s) is (are) correct in relation to ERBB2 alterations: *
17) In Muscle invasive bladder cancer the following statement(s) is (are) correct in relation to response to Chemotherapy: *
18) Which of the statements concerning molecular subtypes of bladder cancer is correct? *
19) Which of the statements concerning therapeutic sensitivity of molecular subtypes is correct? *
20) Which immunohistochemical markers are the most effective to predict molecular subtypes of bladder cancer? *
21) The death for prostate cancer at 5 years is approximately: *
22) The majority of patients that die of prostate cancer are? *
23) The presence of stromogenic carcinoma in a prostate biopsy: *
24) The most common reason for abandoning active surveillance is *
25) The greatest number of cores that should be placed in each block is: *
26) The most common clinical stage today at diagnosis of prostate cancer is: *
27) Which of the following is supportive of a diagnosis of intraductal carcinoma of the prostate (IDC-P)? *
28) An incidental renal mass was detected radiologically in a 58-year-old woman who presented with back pain. The diagnosis on Nephrectomy was Mucinous Tubular Spindle Cell Carcinoma (MTSCC) of the kidney. Which of the following features are associated with this tumor? *
29) What is the immunohistochemical staining pattern for adenoid cystic carcinoma of urethra? *
30) Which of the following tumors is negative for GATA3 on immunohistochemical staining? *
31) A 74 year old male with a prior history of ischemic heart disease and adenocarcinoa of
prostate (Gleason score 3+4=7, Grade Group 2) treated with radiation therapy presents
with serum PSA level of 102 ng/mL. Multiple prostate biopsies were performed.

What is the diagnosis for the morphologic and IHC finding shown in the images?
The last image is synaptophysin immunostain.

Image 1 of 3

Image 2 of 3

Image 3 of 3
32) A otherwise healthy 62 year old man presents with an elevated PSA.  Prostate core
biopsies demonstrate the following lesion in 20% of 1 of 12 cores based on the Gleason score/
grade grouping finding in this case. 

Which of the following is the most appropriate next step for the patient?

33) Clinical history
  • 61 year-old male
  • Elevated serum PSA levels: 6 ng/ml
  • Multiple prostatic biopsies performed
What is the diagnosis?
Image 1 of 4

Image 2 of 4

Image 3 of 4